Surfactant Protein D Gene Regulation

Regulation of lung surfactant protein gene expression.

Surfactant, a complex mixture of lipids and proteins, produced by the alveolar type II cells of the lung epithelium maintains alveolar integrity and plays important roles in the control of host defense and inflammation in the lung. Surfactant protein (SP) A, B, C and D genes are expressed in a cell-type restricted manner by the Clara and/or alveolar type II cells of the lung. Surfactant protein...

Regulation of surfactant protein D in the rodent prostate

BACKGROUND Surfactant protein D (SP-D) is an innate immune protein that is present in mucosal lined surfaces throughout the human body, including the male reproductive tract. In the present study, we characterized the regulation of SP-D expression in the mouse and rat prostate. METHODS Real time reverse transcriptase polymerase chain reaction (RT-PCR) and immunostaining were used to character...

Understanding the regulation of surfactant gene expression.

Among a number of biochemical and morphological criteria, alveolar type-II epithelial cells are defined by the synthesis of surfactant proteins. These molecules are implicated in numerous human diseases such as neonatal respiratory distress syndrome [1] and possibly acute respiratory distress syndrome (ARDS) [2], where a better understanding could lead to new therapeutic modalities via a target...

Surfactant Protein D Inhibition of Human

Surfactant protein-D and pulmonary host defense

Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and secreted by alveolar and bronchiolar epithelial cells, but is also expressed by epithelial cells lining various exocrine ducts and the mucosa of the gastrointestinal and genitourinary tracts...